Abstract: At present, a lot of researches on the modeling method of the main girder of the curved bridge have been carried out, but its practicality still has some shortcomings, especially lack of the numerical simulation method of the main girder under different lower parts of the structure. Based on the Jing-Kai overpass, this paper establishes a numerical model of the main girder of the curved bridge with different radius of curvature, bridge width and lower support form. Furthermore, the error law of the single-girder method model, the spine method model and the grillage method model in the bridge earthquake response is discussed by using the deformation of side support and middle pier shear as the key structure. Advices for the main girder modeling method of different types of curved bridges are proposed, which are helpful to improve the modeling accuracy and efficiency in the seismic design of curved bridges.