Abstract: Based on the theory of polynomial response surface model, a method for accurately constructing wind load response surface model of radar antennas is proposed. Firstly, the sample points design matrix is constructed by Optimal Latin Hypercubes Design of Experiment (DOE) procedure. Secondly, the customization and automation of data flow and work flow are realized by means of secondary development of commercial software, and each process is integrated in iSIGHT platform. Finally, the fitting accuracy of response surface models were checked by Leave-one-out Cross Validation method. The results show that the wind load analysis method based on response surface model is fast in calculation and good in convergence. It can meet the engineering accuracy requirements, and is convenient for multi-person collaborative work. In all, this method has high engineering application value.