Abstract: To mitigate the seismic-induced responses of cable-stayed bridges in the transverse direction, a transverse seismic mitigation system of cable-stayed bridges with pre-pressed spring self-centering energy dissipation braces was proposed in this study. A parameter design method for the braces was developed. Taking a cable-stayed bridge as the study example, the brace parameters were designed and the time history analysis of the tower-beam fixed system and the seismic mitigation system with braces were carried out. The seismic performance of the braced systems was analyzed in terms of the seismic responses at key locations, the energy dissipation capabilities, etc. The results show that the seismic mitigation system of the cable-stayed bridge with pre-pressed spring self-centering energy dissipation braces in the transverse direction utilizes the good hysteretic energy dissipation characteristics of the braces to reduce the displacement and strain of the bridge tower, improve the force distribution of the bridge tower and reduce the residual displacement of the beam. Cable-stayed bridges with pre-pressed spring self-centering energy dissipation braces has good mitigation and control effects on the seismic responses, which is a prominent and promising seismic resistance system.