Abstract: Hawaiian Islands have long been impacted by tsunamis caused by the Pacific seismic zone and near-field seismic zone, largely attributed to its special geographical location and its offshore geography. How to accurately calculate the tsunami runup along the coast of Hawaiian Islands is of great significance on the design of marine structures. Based on the nonlinear shallow water equation, NEOWAVES is a shock-capturing, dispersive wave model for tsunami generation, basin-wide evolution, and run-up. It utilizes non-hydrostatic pressure and vertical velocity terms to describe dispersion and time-varying seafloor deformation. In this study, the NEOWAVES model is applied to the simulation of generation, propagation and runup of the 1946a Aleutian historical tsunami at Oahu Island. The result shows that the tsunami runup data at Oahu Island (North, West and South) calculated by NEOWAES model are similar to the historical recorded runup data, which proves that the NEOWAVES is rational and reliable to simulate tsunami, and offers reasonable reference on design of marine structure.