Abstract: In order to study the destructive mechanism of the frame structure crossing a ground fissure and the dynamic response of the site with ground fissure under an earthquake, a shaking table model test with the scale of 1:15 is carried out, which is based on the background of the Xi'an ground fissure f4 and the laws of similarity. The interaction model for the soil and superstructure is established by the finite element program ABAQUS. By comparing the calculated results with the experimental results, a good consistency has been shown and the feasibility of numerical simulation method has been verified. The results indicate that:the site with a ground fissure has an amplification effect on the acceleration of the soil layer, and the maximum acceleration of the same soil layer appears in the hanging wall near the ground fissure; the site with ground fissure has a great impact on the seismic response of the frame structure under an earthquake, and the impact from the hanging wall is greater than that from the foot wall; the PGA and type of input motions play important roles in structural damage. The research results provide a basis for the design of structures crossing a ground fissure.