Abstract: Time-dependent theory has been proven to be more accurate and reliable for safety analysis of structures during construction compared to the traditional static method based on probability. However, applications are restricted in partial periods and partial structures because of the immeasurable artificial intervention. By inducting 4D technology to safety analysis of time-dependent structures during construction, a visualized environment is provided, where the entire analysis data including structure models are accessible according to the construction schedule. Thus, continuously and dynamically time-dependent analysis is achieved. This idea simplifies the process and enhances the efficiency of structure calculation. This paper demonstrates that the organic combination of 4D technology and time-dependent theory is feasible, proposes the 4D safety analysis model of time-dependent structures and the corresponding method for safety analysis, and presents a system for 4D-based construction management and safety analysis.