Abstract: The inherent dynamic characteristics of different buildings vary a lot. The structural stiffness-flexibility indicator is expressed by the structural height and fundamental period of buildings. The stiffness and flexible properties of the structures will make the seismic displacement response and acceleration response of the buildings different, resulting in different post-earthquake losses. The rigid frame (RF) and the flexible frame (FF) designed according to the current codes are studied. In accordance with the seismic resilience evaluation standard of China, the seismic resilience evaluation of the high-rise steel frame structures is conducted based on the elasto-plastic time history analysis under the action of fortification earthquake and rare earthquake and the component fragility obtained from the building information model. The results show that the response of inter-story drift of RF is smaller and the response of floor acceleration is larger, while the response of FF is the opposite. This shows that the proportion of costs and time of repairmen, as well as personnel losses of various structural and non-structural components, are related to the structural stiffness-flexibility indicator.