Abstract: The discontinuity of internal rotation angle caused by over constraint will lead to the inaccuracy of the full-field structural deformation reconstruction. Taking a typical three-dimensional panel structure at the aircraft inlet as a research object, the full-field deformation reconstruction for a statically indeterminate structure was investigated. By combining the inverse finite element method with a subregion division method, the reconstruction of the full-field structural deformation can be achieved upon measured strain data. The numerical simulation study on the full-field deformation reconstruction of a three-dimensional panel structure under a static load was conducted to verify the feasibility and accuracy of the algorithm. Experimental study was further conducted, full-field structural deformation of three-dimensional panel under varying loading was reconstructed upon the measurement strain, and the accuracy of the reconstructed deformation field was verified by the measured deformation data. Study results show that: the relative errors between the reconstructed deformation value and the measured deformation value at the deformation measuring point is about 10%, the deformation reconstruction algorithm based on inverse finite element method with subregion division can reconstruct the full-field deformation of a three-dimensional panel.