Seismic fragility analysis can be used to predict and assess the seismic risk of structures by quantitatively establishing the relationship between seismic intensity and structural damage. This paper aims to evaluate the seismic capacity of frame-supported multi-ribbed composite wall structure under different seismic intensities. Models of the whole building are constructed in OpenSEES, which use the simplified frame-equivalent diagonal brace model of multi-ribbed composite wall, and the influence of different parameters on the seismic performance of the structure is studied based on the Incremental Dynamic Analysis (IDA) and fragility analysis. The results show that the change of the stiffness ratio of the transfer floor has significant impact on the structural performance. Uniform arrangement of the structure along the vertical direction can improve the seismic resistance. It is suggested that: the stiffness ratio of the frame structures with multi-ribbed composite wall in areas with an seismic intensity of 8 should be 1.0 - 2.5; the number of ribbed columns and block strength can affect the seismic performance of the structure, which should be reasonably selected; and the concrete strength has significant effect on the seismic performance of the structure, and concrete with higher grade should be adopted in practice while the code requirements should be satisfied.