Abstract: This article made the research on the vertical shear strength of a cellular beam under different parameters. Based on the test, a reasonable finite element model is established. Through the calculation of a cellular beam of different hole types, flange sizes and opening rates, we can obtain shear bearing capacity of the cellular beam under different parameters. The results show that: in the cases of the same hole rate and hole numbers, the shear strength of the circular hole cellular beam is better than that with hexagon or rectangular holes’; the flange width variation has little effect on shear strength, but the thickness variation has great effect on it. It was found that the simplified shear strength calculation formula considering the shear contribution and opening rate was affected by the joint action of the hole types, flange widths and opening rates. By analyzing the cellular beam stress performance of different shear span ratios, we can gain the formula for bending-shearing deformations.