Abstract: The seismic response analysis of the structure considering both topographic effect and soil-structure dynamic interaction simultaneously is a difficult problem in earthquake engineering research. Based on the viscous-spring superposition artificial boundary theory, a finite element model accounting for the incident angle, soil-structure dynamic interaction and topographic effect is built by using the ANSYS and a seismic response analysis of a five-span continuous beam bridge was carried out by the method. The numerical results demonstrate that the internal force changes with the increasing of incidence degrees; the internal force is magnified in a certain site because of the local topographic effect; compared with considering the soil-structure dynamic interaction effect, the internal force is smaller without such effect; simultaneously, physical properties of soil play a certain role in analysis of soil-structure dynamic interaction effect.