Abstract: The influence of groundwater seepage on stability of soil and rock slope is analyzed.The analytic solution of stability of water-penetration soil and rock slope is set up under ground water seepage.The most dangerous circle slip surface is located with DFP change-scale method of nonlinear programming.In the condition of high pore-hydraulic pressure,the most dangerous circle slip surface is located with Fellenius Method and DFP change-scale method.Then the safety factor of the most dangerous circle slip surface is evaluated with Spencer method or Morgenstern-Price method.The influence coefficient of seepage on slope stability is calculated in a cutting slope.