Abstract: Using the same parameters, buffeting response of a cable-stayed bridge is analyzed respectively by time domain method and frequency domain method. The vibration shape, RMS, PSD of the buffeting response are studied to check the reliability of time domain analysis method for bridge buffeting. In time domain buffeting analysis, wind velocity field for the cable-stayed bridge is simulated by the spectral representation method. Buffeting force is adopted in quasi-steady form, and self-excited force is adopted in the form proposed by Lin. An iterative process is presented for the nonlinearity of self-excited force. The motion equations of overall bridge are solved by the Newmark-β method. In frequency domain buffeting analysis, multi-mode coupled buffeting analysis method is adopted. It is shown that the analysis results by the two methods agree well with each other, and time domain analysis method for bridge buffeting response is feasible and reliable.