Abstract: The dynamic interaction between high-speed train and bridge is studied by theoretical analysis and field test. A computational model of train-bridge system is established. Each vehicle is described by 27 degrees of freedom. The bridge is modeled by modal superposition technique. The measured track irregularities are taken as the system excitation. The whole histories of the China-Star High-Speed Train running through a bridge with 24m double track prestressed concrete box girders on the Qinghuangdao-Shenyang Special Passenger Railway in China are simulated. The dynamic responses of the bridge such as deflections, lateral amplitudes, lateral and vertical accelerations, lateral pier amplitudes, and the vehicle responses such as derail factors, offload factors and wheel-rail inter-thrusts are calculated and compared with the experimental results.