Abstract: A parametric optimization algorithm of multiple tuned mass damper(MTMD) systems considering confinement of the relative displacement response of TMDs is proposed for the practical use of the wind-induced vibration control of the hangers on Jiujiang bridge.The parametric optimization design of an MTMD system which is attached to a hanger on Jiujiang bridge is studied.It is found that the relative displacement response of TMDs is so large as to induce the components damage of TMDs,reduce the vibration control efficiency and increase the maintenance cost.The improved parametric optimization algorithm offers more reasonable results.