Abstract: Finite element model of hybrid structure of new cable-stayed bridge with giant wheel was established in order to study the pressure coefficient distribution of Tianjin CiHai Bridge. The RNG k- of RANS model was adopted as the turbulent model of CiHai Bridge and the non-equilibrium wall function was used to analog the complex flow phenomenon around the wall. Through the numerical analysis of the flow phenomenon around the cable-stayed bridge by means of numerical wind tunnel, the speed distribution of the flow field around the cable-stayed bridge and the wind-pressure coefficient distribution in the surface of the cable-stayed bridge were obtained. With tunnel test, the pressure coefficients from different directions of 32 measuring points were acquired. The theoretical value of numerical wind tunnel and the wind tunnel test value were compared, and the result showed that they are uniform and the pressure coefficient distribution can be used for the project. Thus to predict the average pressure distribution of the surface of cable-stayed bridges, the numerical simulation method adopted in this paper could be generalized.