Abstract: he controlled bodies are constructed by discretizing the high-rise structure along its height direction, and then, their dynamics equations are established by using Timoshenko beam theory, which are 2 sets of equations describing the relationships of body translation vs. transverse shear, and body rotation vs. bending moment respectively. Thus, using the two sets of equations alternately in time domain, a numerical algorithm based on wave analysis is presented for the dynamic response analyses of high-rise structures under seismic loading. The dynamic response of Nanjing TV tower under seismic loading is analyzed using the proposed algorithm. It is found the maximum displacement of big observation deck, who suffers the maximum rotational inertia moment, is greater than that predicted by the finite element method, indicating the rotational inertia moment should not be neglected when the dynamic response of high-rise structure is investigated. The algorithm presented provides an effective approach for dynamic response analysis of high-rise structure under seismic loading.