Abstract: In this paper, the nonlinear time-history analysis of a five-span continuous viaduct bridge under E2 earthquake motion is carried out in the longitudinal direction and transverse direction of the bridge separately. And the seismic performance of these partially concrete-filled steel bridge piers of Viaduct Bridge is evaluated. The NS and EW components of seismic waves recorded at the Japanese Metrological Agency (JMA) in the 1995’s Hyogo-ken Nanbu Earthquake and special seismic analysis program TDAPⅢ (time domain 3-dimensional dynamic analysis program) are used in this analysis. In this analytical model, these piers are idealized by a 3-D fiber element; the superstructure and abutment are idealized by a 3-D beam element; the foundation and bearing are idealized by a spring element. From analytical results, it is found that the responsive displacement and force of piers in the transverse direction of the bridge is larger than that of the longitudinal direction. And it is found these piers of Viaduct Bridge should be safe under E2 earthquake motion, too.