Abstract: In response to the threat of heavy truck impacts on precast segmental reinforced concrete (PSRC) bridge piers, numerical simulation and analysis were carried out on the dynamic behavior of PSRC bridge piers under heavy truck impacts using finite element (FE) program LS-DYNA. Refined FE models of the prototype PSRC bridge pier and heavy truck were established and validated by reproducing existing impact tests. Moreover, the dynamic response and damage of the PSRC bridge pier and the cast-in-place monolithic reinforced concrete (CMRC) bridge pier under heavy truck impact were compared. The study reveals the factors that influence the truck impact resistance of PSRC bridge piers, e.g., impact eccentricity, impact angle, number of segments, initial prestress, and shear key. The results show that the PSRC bridge pier experiences a shear failure under heavy truck impact. Compared with the CMRC bridge pier, the PSRC bridge pier presents better truck impact resistance with smaller peak impact force, lateral deformation and reduced damage due to the discontinuity, relative sliding, and friction energy dissipation between segment joints, as well as the interaction of the tendons and shear key. The impact resistance of the PSRC bridge pier increases with the increase of impact eccentricity, initial prestress, and the reduction of segment number, while the impact angle and shear key have a relatively less effect on the impact resistance of PSRC bridge pier.