Abstract: Based on the "Standard for seismic resilience assessment of buildings" GB/T 38591−2020, the seismic resilience of a high-rise RC frame structure office building with high-strength concrete in 7-degree (0.1g) fortification earthquake zone was evaluated in this research. A quantitative analysis was conducted on the resilience assessment indicators of post-earthquake repair cost, repair time and personnel casualties, as well as the changes in the seismic toughness evaluation results, in terms of improving the damping ratio of the structural system (energy dissipation retrofitting), changing the seismic performance of structural and non-structural components, and changing the seismic performance parameters of elevator. The results show that increasing the damping ratio of the structural system through energy dissipation retrofitting technology can significantly reduce the seismic response of the structure, and the three resilience indexes show varying degrees of decline. The impact of changes in structural component on building repair time and personnel casualties is significantly higher than that of non-structural components. Improving the seismic performance of the structural components can significantly reduce repair time and personnel casualties. The impact of changes in seismic performance of non-structural components on post-earthquake repair costs is significantly higher than that of structural components. Enhancing the seismic performance of non-structural components can significantly reduce repair costs. Moreover, improving the seismic performance parameters of elevators can significantly shorten the repair time. The research results can provide guidance for improving seismic resilience design of buildings with different targets.