Abstract: At present, the fatigue design for solid-web steel reinforced concrete (SRC) girders is not specified in domestic and foreign codes, which undoubtedly limits the application of SRC structures under fatigue loading conditions. Based on a series of experimental and numerical results of fatigue behaviors of SRC girders, this study proposes a fatigue design method for SRC girders, which can provide a reference for practical engineering design. The safety of the whole SRC beam is ensured by carrying out fatigue design for each key component inside SRC girder separately. Among them, the SRC-H-steel, as the most important component inside SRC girders, was designed by modifying the S-N fatigue curve for existing bare H-steel beam in current codes, and the correction coefficient was obtained upon the regression analysis of a large amount of data. For the longitudinal tensile bars inside SRC girders, the fatigue design S-N curve was fitted according to experimental data, and the influence of stress ratio was considered. For the concrete in compression zone of one SRC girder, although no fatigue failure occurred in experimental investigations, the existing methods in the current fatigue design code for concrete structures are adopted conservatively. Finally, the fatigue design method proposed is verified according to previous experimental results, which shows that the design method is reasonable and reliable.