Abstract: The adoption of hybrid structures composed of concrete-filled steel tube (CFST) columns, steel beams, and light steel frames can reasonably apply light steel structures originally only suitable for low or multi-story buildings to high-rise buildings, and the reasonable optimization of the structural form of the light steel subframe and the connection method with the main structure is conducive to improving its assembly rate. To investigate the seismic performance of the new sleeve-type vertical connection of the main and secondary structures in the "hinge-rigid joint" semi-frame connection scheme (scheme of hinged-rigid connection, SHRC) to release the axial force of the subframe columns, low-cycle reciprocating loading tests on three subframe light steel columns and main structural steel beam subassemblage specimens were carried out, and the force transmission mechanism and failure mode of the sleeve-type connection were then analyzed. Based on the test results, the SHRC was further optimized, and a "fully hinged" connection scheme (scheme of fully hinged connection, SFHC) with higher assembly rate and more convenient construction was proposed. Taking a demonstration project as an example, the strong earthquake nonlinear dynamic time history analysis of the high-rise CFST column-steel beam-light steel frame hybird structure with SHRC and SFHC connection schemes was carried out, and the differences in structural energy dissipation, in structural dynamic response, and in component performance state were compared. The results show that the plastic energy dissipation, maximum inter-story drift ratio, and top displacement amplitude of the hybird structure increase slightly when the SFHC is adopted compared with the SHRC. However, both structures have good seismic performance, verifying the rationality of using the "fully hinged" connection scheme for high-rise hybrid structures.