Abstract: According to the problem that the radial cable of a wheel spoke structure may be compressed due to the large change of the height of its outer ring, the rigid strut is introduced to replace the partially compressed radial cable, which solves the problem that the traditional wheel spoke structure cannot be formed. The prestressed state solution formula of the wheel spoke structure is deduced, considering the influence of the self-weight of the structure and the weight of the cable clamp, etc., the elevation of each node of the inner ring is determined through repeated iterations, and the form-finding method for the hybrid cable-strut structure analysis is formed. The mechanical performance of the wheel spoke structure with large height difference is analyzed comprehensively, and the influence of the parameters such as the height difference of the outer ring, the radial cable tie rod and the additional ring cable are investigated. The analysis results show that: the wheel spoke structure with large-height-difference is relatively unfavorable when it is subjected to the half-span live load and wind loading in the long axis direction, but the failure of individual radial cables or struts will not cause the structure to collapse continuously. As the height difference of the outer ring increases, the number of struts increases accordingly, the internal force of the members on short-axis and the upper radial cable on long-axis increases, and the internal force of the lower radial cable on long-axis decreases. Tie rods are arranged in the middle of the long radial cable, which can effectively coordinate the deformation between the upper and lower radial cables. By setting additional ring cables near the long axis, the vertical stiffness of the roof support structure can be improved by strengthening the connection between the adjacent radial cables. The forming method of setting rigid struts in the wheel spoke structure with large height difference has been successfully applied to the Xiamen New Sports Center Stadium Project.