Abstract: The existing design method for the spatial structure in Chinese specifications fails in precisely considering the uncertainties of random variables, for taking a rough and experiential global safety factor. The uncertainty of loads and structure are not considered in the existing design method. The kiewitt8 single-layer latticed dome structures are selected for a global stability analysis. The probabilistic models of loads and structures are built, the Monte Carlo Simulation (MCS) and Response Surface Method (RSM) are both carried out for constructing the limit state equations of real loads and structural resistance, and then the failure probability and reliability index of the structure are computed based on FORM. The design method in <Technical specification for space frame structures> (JGJ 7−2010) is calibrated, the structural limit state equations are constructed based on the global safety factor design formula in the specification, and then the failure probability and indexes of reliability of structures are obtained. The analysis results show that: the design method in existing specification underestimates the structural reliability, and the design method should be revised based on full probability global reliability analysis method.