Abstract: In order to analyze the dynamic response of PE gas pipeline under vehicle loading, the virtual prototype system simulation software ADAMS and the finite element analysis software are used to study vehicle moving loads and the mechanical characteristics of buried PE gas pipeline under the loads. A vehicle-pavement-soil-pipeline model is established, and the simulation results are verified by measured values. Based on the vehicle dynamic load spectrum extracted by virtual prototype system simulation, the dynamic response process of PE gas pipeline is analyzed, and the dynamic response law of buried PE gas pipeline under different vehicle weights and speeds is studied. The results show that: the stress and displacement of the tube increases with the increase of vehicle weight; the stress on the pipe increases with the increase of the vehicle speed, and its displacement decreases with the increase of the vehicle speed.