Abstract: To provide economic decision support for structural protection against blasting terror attacks, and to achieve the optimal balance between protection performance and cost, an economic decision model for blast-resistant protection measures of structures was established in terms of the relationship between cost of land and blast protection measures and the standoff distance. Based on practical engineering data of protection costs for anti-blasting, key parameters of the prediction model were determined by the trust-region optimization algorithm. The effectiveness of the established model was verified with novel project data. The results show that the prediction model can be used in the economic analysis for the blast resistant protection measures in a simple and effective manner, which provides evidences for blast security risk assessment and management decision.