Abstract: The energy absorption of an explosion-proof wall by its own deformation can effectively reduce the damage of the explosion shock wave to the target. Using the one-dimensional stress wave theory and the finite element analysis program ANSYS/LS-DYNA, the explosion isolation and energy absorption of aluminum foam sandwich explosion-proof walls, polyurethane explosion-proof sandwich walls and concrete sandwich explosion-proof walls are analyzed. The results show that aluminum foam sandwich explosion-proof walls perform the best on energy absorption, concrete sandwich explosion-proof walls come to the second, and polyurethane sandwich explosion-proof walls perform the worst. Protective effects of anti-blast walls is dependent on the distance from the wall to the measuring points. As the distance increases, the protection rate increases. Explosion-proof wall performance depends on not only the deformation of anti-blast walls, but also the strength of anti-blast walls.