Abstract: Seismic risk quantification has become necessary as it is a required component in estimating direct monetary losses, downtime, and fatalities. Firstly, dynamic history analysis was conducted on a Fiber Reinforced Concrete (FRC) structure by means of incremental dynamic analysis (IDA) method in the paper, and an IDA curve was attained. On the basis of this IDA curve, the seismic fragility curve was derived. According to the seismic fragility curve and the epistemic uncertainty, the seismic fragility curve considering epistemic uncertainty was determined. Combining the seismic fragility curve considering epistemic uncertainty with the seismic hazard curve, the seismic risk was then evaluated. Then, an evaluation procedure of seismic risk of structures is presented in the paper, which is based on the simplified methodology proposed by Laura Eads. An 8-story FRC framed structure and an 8-story reinforced concrete (RC) framed structure which were designed according to the current Chinese codes were analyzed. The results show that the seismic risk with the simplified methodology is higher than that with the existing methodology for both the FRC framed structure and the RC framed structure, the errors were 5.7% and 8.0% respectively, and it is feasible and conservative to use the simplified methodology to evaluate the seismic risk.