Abstract: Two one-bay two-story 1/3 scale concrete-filled square steel tubular (CFST) frame-thin steel plate shear walls (SPSWs) with two-side openings and no openings in the infill panels were studied to investigate the seismic behavior under low cyclic loading. The mechanical behavior and failure mechanism were investigated on the CFST frame-thin SPSWs. The nonlinear analytical analysis was conducted using the finite element package ABAQUS. The numerical results were compared with the experimental results to study the seismic behavior of the CFST frame-thin SPSWs. The results showed that the CFST frame-thin SPSWs with two-side openings and no openings in the infill panels both had high bearing capacity, energy dissipation capacity and stiffness. Ideal failure mechanism, namely weak plate strong frame, and the double aseismic fortification aim were achieved. The effects of opening ratio and axial compression ratio on the structural aseismic behavior were investigated by the finite element prototype models. The results showed that the bearing capacity and energy dissipation capacity decreased with the increase in the opening ratio, and the increase in the opening ratio had little effect on the degradation of stiffness. Axial compression ratio had little effect on the bearing capacity, energy dissipation and stiffness.