不同扩张尺度对非对称椎动脉支架力学性能影响的研究

王惟颢, 冯海全, 朱明新, 刘佳

王惟颢, 冯海全, 朱明新, 刘佳. 不同扩张尺度对非对称椎动脉支架力学性能影响的研究[J]. 工程力学, 2017, 34(3): 232-240. DOI: 10.6052/j.issn.1000-4750.2015.09.0735
引用本文: 王惟颢, 冯海全, 朱明新, 刘佳. 不同扩张尺度对非对称椎动脉支架力学性能影响的研究[J]. 工程力学, 2017, 34(3): 232-240. DOI: 10.6052/j.issn.1000-4750.2015.09.0735
WANG Wei-hao, FENG Hai-quan, ZHU Ming-xin, LIU Jia. INFLUENCE OF DIFFERENT DILATATION SIZE ON MECHANICAL PROPERTIES OF ASYMMETRIC VERTRBRAL ARTERY STENTS[J]. Engineering Mechanics, 2017, 34(3): 232-240. DOI: 10.6052/j.issn.1000-4750.2015.09.0735
Citation: WANG Wei-hao, FENG Hai-quan, ZHU Ming-xin, LIU Jia. INFLUENCE OF DIFFERENT DILATATION SIZE ON MECHANICAL PROPERTIES OF ASYMMETRIC VERTRBRAL ARTERY STENTS[J]. Engineering Mechanics, 2017, 34(3): 232-240. DOI: 10.6052/j.issn.1000-4750.2015.09.0735

不同扩张尺度对非对称椎动脉支架力学性能影响的研究

基金项目: 国家自然科学基金项目(81160186);内蒙古自治区自然科学基金项目(2015MS0803)
详细信息
    作者简介:

    王惟颢(1990-),男,廊坊人,硕士生,主要从事机械设计及理论研究(E-mail:wwh123adsl@163.com);朱明新(1972-),男,呼和浩特人,讲师,硕士,主要从事机械设计与理论研究(E-mail:mcjwzx@imut.edu.cn);刘佳(1979-),女,呼和浩特人,讲师,博士,主要从事机械设计与理论研究(E-mail:liujiajing1979@163.com).

    通讯作者:

    冯海全(1972-),男(蒙族),呼和浩特人,教授,博士,主要从事机械设计及理论研究(E-mail:fhq515@163.com).

  • 中图分类号: R318.11

INFLUENCE OF DIFFERENT DILATATION SIZE ON MECHANICAL PROPERTIES OF ASYMMETRIC VERTRBRAL ARTERY STENTS

  • 摘要: 在临床治疗中,不同尺寸的狭窄血管所需要支架扩张的尺度也不同,而支架的扩张尺度对其力学性能有着重要影响。利用有限元方法仿真模拟分析了三款不同支架的体外扩张过程,主要研究了结构相同时不同扩张尺度对支架力学性能的影响。结果显示:随着支架扩张直径的增大,支架的最大等效应力、轴向短缩率、扩张不均匀性及柔顺性能呈递增趋势,支撑刚度和静安全系数呈递减趋势;支架的径向回弹主要受到其材料和结构影响,扩张尺度并不起决定性作用;通过与实验结果相比对,理论值与实验值结果吻合较好,误差在7%以内,验证了有限元模拟的准确性及合理性;利用动物实验对支架治疗效果进行验证,表明了支架的植入治疗是安全且有效的。综合考虑各因素影响,支架的治疗效果受支架扩张尺度的影响较大,这为临床治疗的顺利实施提供了良好的理论依据。
    Abstract: In clinical treatment, stenosed vertebral arteries with different diameter require different dilatation size of stents. The dilatation size of a stent has a great influence on its mechanical properties. The finite element method was used to simulate and analyse the expansion process in vitro of three different stents to investigate the effect of different dilatation size on stents' mechanical properties with the same structure. Results showed: 1) with the increase in the final expansion diameter of stents, the maximum equivalent stress, axial shortening rate, expansion non-uniformity and flexibility of the three stents had an increasing tendency, while radical bracing stiffness and static safe-value decreased; 2) the radial spring-back of stents was mainly influenced by the material and structure, the dilatation size didn't play the decisive role; 3) comparisons showed that the theoretical and experimental data matched well, and the error values were under 7% which proved the veracity and rationality of the finite element simulation; 4) the treatment effect of stents was verified with animal experiment, and the result showed the implantation of stents was safe and effective. This study proved the dilatation size has a great influence on the treatment effect of stents. In the meantime, it is expected to offer a theoretical basis for the smooth implementation of clinical treatment.
  • [1] 王林, 周清安, 徐建银. 椎动脉起始部重度狭窄患者支架置入与药物治疗的疗效比较[J]. 中国现代药物应用, 2014, 8(1):13-14. Wang Lin, Zhou Qing'an, Xu Jianyin. Clinical observation of the initiation part of vertebral artery stenosis stenting versus pure drug treatment:a randomized and comparative study[J]. Chinese Journal of Modern Drug Application, 2014, 8(1):13-14. (in Chinese)
    [2] 杨慧茹. 椎动脉狭窄与后循环缺血的相关性研究[D]. 天津:天津医科大学, 2012:5-6. Yang Huiru. The study on Vertebral artery stenosis and posterior circulation ischemia[D]. Tianjin:Tianjin Medical University, 2012:5-6. (in Chinese)
    [3] Francesco M, Lorenza P, Valeria M. A predictive study of the mechanical behavior of coronary stents by computer modeling[J]. Medical Engineering & Physics, 2005, 27(1):13-18.
    [4] Walke W, Paszenda Z, Flipiak J. Experimental and numerical biomechanical analysis of vascular stent[J]. Journal of Materials Processing Technology, 2005, 164(20):1263-1268.
    [5] Lorenza P, Francesca G, Ferdinando A. Numerical investigation of the intravascular coronary stent flexibility[J]. Journal of Biomechanics, 2004, 37(4):495-501.
    [6] 李萍萍, 张若京. 具有周期结构的血管支架有限元分析[J]. 工程力学, 2012, 29(9):369-374. Li Pingping, Zhang Ruojing. Finite element analysis of stent with periodic structure[J]. Engineering Mechanics, 2012, 29(9):369-374. (in Chinese)
    [7] 冯海全, 江旭东, 胡志勇, 张烨. CoCr合金冠脉支架扩张变形的生物力学性能研究[J]. 功能材料, 2012, 43(增刊II):182-186. Feng Haiquan, Jiang Xudong, Hu Zhiyong, Zhang Ye. Research on biomechanical performance for CoCr alloy coronary stent in expansion[J]. Functional Materials, 2012, 43(Suppl II):182-186. (in Chinese)
    [8] 刘新峰, 张弢, 冯海全, 王永刚, 魏继昌, 王大伟. 一种椎动脉支架[P]. 江苏, 中国:CN203425070U, 2014-02-12. Liu Xinfeng, Zhang Tao, Feng Haiquan, Wang Yonggang, Wei Jichang, Wang Dawei. A kind of vertebral artery stents[P]. Jiangsu, China:CN203425070U, 2014-02-12. (in Chinese)
    [9] 刘新峰, 张弢, 冯海全, 王永刚, 魏继昌, 王大伟. 一种椎动脉支架[P]. 江苏, 中国:CN103300951A, 2013-09-18. Liu Xinfeng, Zhang Tao, Feng Haiquan, Wang Yonggang, Wei Jichang, Wang Dawei, et al. A kind of vertebral artery stents[P]. Jiangsu, China:CN103300951A, 2013-09-18. (in Chinese)
    [10] 冯海全, 李新, 冯健, 孙丽丽. 非对称椎动脉支架变形机理的有限元分析[J]. 机械设计与研究, 2015, 31(1):54-57. Feng Haiquan, Li Xin, Feng jian, Sun Lili. The research based on the finite element analysis on the mechanical of the asymmetric deformation of the vertebral artery stents[J]. Machine Design and Rasearch, 2015, 31(1):54-57. (in Chinese)
    [11] 张站柱, 乔爱科, 付文宇. 不同连接筋结构的支架治疗椎动脉狭窄的力学分析[J]. 医用生物力学, 2013, 28(1):48-52. Zhang Zhanzhu, Qiao Aike, Fu Wenyu. Mechanical analysis on treatment of vertebral stenosis by stents with different links[J]. Journal of Medical Biomechanics, 2013, 28(1):48-52. (in Chinese)
    [12] 张站柱, 乔爱科, 付文宇. 不同连接筋结构的支架治疗椎动脉狭窄的血流动力学数值模拟[J]. 医用生物力学, 2013, 28(1):122-127. Zhang Zhanzhu, Qiao Aike, Fu Wenyu. Hemodynamic simulation of vertebral artery stenosis treated by stents with different links[J]. Journal of Medical Biomechanics, 2013, 28(2):122-127. (in Chinese)
    [13] Feng Haiquan, Guo Feifei, Liu Changzeng, Shuzou Yamashita. Research on the elastic and plastic deformation of CoCr alloy used for coronary stents[C]. Shanghai:Advances in Heterogeneous Material Mechanics, 2011:1150-1154.
    [14] 江旭东, 冯海全, 胡志勇, 刘海. 球囊扩张式冠脉支架的动静态扩张过程的变形机理研究[J]. 机械强度, 2012, 34(3):450-454. Jiang Xudong, Feng Haiquan, Hu Zhiyong, Liu Hai. Research on deformation mechanism for balloon- expandable intracoronary stents in static and periodic expansion[J]. Journal of Mechanical Strength, 2012, 34(3):450-454. (in Chinese)
    [15] 江旭东, 滕晓艳, 史冬岩, 张永峰. 冠脉支架联接体波形对血管损伤与再狭窄的影响[J]. 哈尔滨工程大学学报, 2015, 36(7):975-980. Jiang Xudong, Teng Xiaoyan, Shi Dongyan, Zhang Yongfeng. Influence of bridging member morphology of coronary stents on vascular injury and in-stent restenosis[J]. Journal of Harbin Engineering University, 2015, 36(7):975-980. (in Chinese)
    [16] 冯海全, 陈彦龙, 何平基, 韩青松, 王志国. 镁合金冠脉支架柔顺性能的模拟研究[J]. 功能材料, 2014(7):7099-7103. Feng Haiquan, Chen Yanlong, He Pingji, Han Qingsong, Wang Zhiguo. Simulation studies on smooth performance for magnesium alloy coronary stents[J]. Functional Materials, 2014(7):7099-7103. (in Chinese)
    [17] 王晓, 冯海全, 王文雯, 张瑞敏, 陈彦龙. 球囊扩张式冠脉支架生物力学性能研究[J]. 中国生物医学工程学报, 2013, 32(2):203-210. Wang Xiao, Feng Haiquan, Wang Wenwen, Zhang Ruimin, Chen Yanlong. Research on biomechanics properties for balloon-expandable intracoronary stents[J]. Chinese Journal of Biomedical Engineering, 2013, 32(2):203-210. (in Chinese)
    [18] 王文雯, 冯海全, 王晓, 陈彦龙, 张瑞敏. 不锈钢冠脉支架体外耦合扩张变形行为研究[J]. 生物医学工程学杂志, 2013, 30(5):1027-1032, 1062. Wang Wenwen, Feng Haiquan, Wang Xiao, Chen Yanlong, Zhang Ruimin. Research on the coupling expansion deformation behavior of coronary stainless steel stent in vitro[J]. Journal of Biomedical Engineering, 2013, 30(5):1027-1032, 1062. (in Chinese)
    [19] 李建军, 罗七一, 谢志永, 李雨. 有限元分析在冠脉支架设计中的应用[J]. 生物医学工程学进展, 2009, 30(2):74-79. Li Jianjun, Luo Qiyi, Xie Zhiyong, Li Yu. Application of finite element analysis in coronary stent design[J]. Progress in Biomedical Engineering, 2009, 30(2):74-79. (in Chinese)
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出版历程
  • 收稿日期:  2015-09-05
  • 修回日期:  2016-02-21
  • 刊出日期:  2017-03-24

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