Abstract: The displacement ratio of asymmetric buildings does not meet specifications of the design codes due to the inconsistency of the mass center and the rigidity center. It is effective to install displacement-based energy dissipative devices to reduce the displacement ratio of asymmetric buildings. However, the parameters and the locations of displacement-based energy dissipative devices determine the torsional response. In order to investigate the torsional response, a two-way eccentric frame structure is analyzed in this paper. An optimization model based on artificial fish swarm and finite element software SAP2000API is proposed for the optimal design of displacement-based energy dissipative devices in asymmetric buildings. The optimization model is designed for real structures which have multi-degrees of freedom to derive the optimum location and parameters of devices. Finally, the optimization model is applied in a multi-storey eccentric structure which does not meet the specifications to obtain the optimal design of displacement-based energy dissipative devices, which is found to be able to control the displacement ratio efficiently.