Abstract: To achieve the flexible decoration of multi-layer-opening venues, to ensure the safety of large-span-giant steel structure and scientific exhibits under the action of all kinds of natural disasters, and to follow the national policy of Energy saving, Land saving, Water saving, Material saving and Environment friendly, isolation technology of large-span-giant steel structure without unified isolation layer on soft soil foundation, construction technology of complex long-span steel structure system, and design and evaluation technology of green building were researched and applied in the largest science venues green building, Guangdong science center. The project carried out macroscopic and microstructure test of soft soil, shaking table test, simulation analysis, pressure-shear test, node experiment test and simulation analysis, construction simulation and energy consumption simulation