Abstract: Parametric analysis on the mechanical performance of concrete filled steel tubular (CFST) columns with internal profile steel under biaxial eccentric compression was conducted in this study. A finite element (FE) model of CFST columns with internal profile steel under biaxial eccentric compression was developed using ABAQUS. The FE model was verified using readily available experimental results. The bearing capacity and deflection curves of typical members were calculated. Parametric analysis in terms of the load eccentricity angle, load eccentricity ratio, strength of materials, steel strength, steel material strength and concrete slenderness ratio were conducted. Results show that steel ratio of tube and profile steel, concrete strength and steel strength of steel have significant effects on the bearing capacity of the CFST columns. With the increase in eccentricity ratio, eccentric angle, aspect ratio and slenderness ratio, the bearing capacity decreases. The strength of profile steel imposes little effect on the bearing capacity.