Abstract: Based on the dynamic model of a pile foundation accounting for the effects of soil-structure interaction, the primary resonance of a pile foundation is investigated. To analyze the effects of main parameters on the dynamic properties of the pile foundation, the effects of these main physical parameters on the effective nonlinear coefficient are examined via a statistical analysis method. Then, the key parameter with the most significant effect on the dynmainc response is selected. Finally, through the numerical results of the comparative study on the influence of the key and non-critical parameters on the frequency-response curves of the primary resonance, the correctness and significance of the kinetic parameters analysis are verified.