Abstract: A dynamic model for isolated high-rise frame-shear wall buildings was presented based on the consideration of interaction of frame and shear wall, in which the shear wall is a system with distributed mass and the frame is a system with lumped mass and spring. According to established dynamic model, the effects of isolated devices and the frame structure on the shear wall structure were introduced into a distributed parameter system using boundary conditions, and frequency equation and mode orthogonal conditions were deduced. Then, according to the Hamilton Principle, the equivalent damping ratio in every mode produced by the damping of laminated rubber bearings was derived, and the seismic response of isolated high-rise frame-shear wall buildings can be obtained by the mode superposition method. Finally, a ten-story isolated frame-shear wall building was chosen to analyze dynamic characteristics and seismic response to validate the correctness of the dynamic model and method of solving for seismic response. Simulation results show that the established dynamic model can reflect the dynamic performance of isolated structure well and seismic response of isolated high-rise frame-shear wall buildings can be solved conveniently by the method in this paper, the results of which are basically consistent with those from finite element methods. At the same time, the method deduced can obtain the interaction process of frame structures and shear-wall structures in isolated high-rise frame-shear wall buildings.