Abstract: In order to compare the influence on the seismic behavior of different connection constructions of a steel frame systematically, an efficient and accuracy finite element model of ABAQUS is used. The accuracy and equivalence of the non-linear fine model and multi-scale model are proved by published steel-frame-connection quasi-static tests at home and abroad. Nine multi-scale models of different connection construction steel frames are established and elastic-plastic time-history analyses are used. The structural deformation, base shear, plastic energy dissipation and fracture tendency index are compared and discussed in depth.The results show that: as long as the design is reasonable, the connection construction differences have little effect on structural deformation and do not cause the stiffness mutation and adverse effects on structures | reinforced connections do not cause the increase of the base shear (little increase up to 6%), which reduce the seismic response and have beneficial effect on structures to resist seismic loading | the change of constructions can significantly improve the fracture tendency at the welded toe to relieve the stress concentration at weld so that make the damage in the base metal but not weld itself in order to avoid brittle ductile occurrence.