Abstract: High-rise office buildings mainly adopt frame-shear wall structures. The whole structure may collapse progressively triggered by initial failure of critical structural element(s), eventually resulting in serious economic losses and social impact. Dynamic progressive collapse analysis was conducted on typical reinforced concrete (RC) frame-shear wall structures and the collapse mechanism was summarized, which provided a basis for rapid assessment for the progressive collapse of RC frame-shear wall structures. The research included the following works: Eighteen typical RC frame-shear structures were designed in accordance with different seismic fortification intensities, span lengths and number of stories. The numerical models of the structures were established in which fiber beam elements and multilayer shell elements were used to simulate RC beams and columns and RC shear walls, respectively. The nonlinear dynamic analysis using nonlinear dynamic alternate path method was conducted on the typical RC frame-shear wall structures, and the dynamic responses of the structures triggered by initial local failures were obtained. The dynamic responses of structural progressive collapse varying with different key parameters were compared and analyzed, by which the influence of different structural parameters on the dynamic progressive collapse responses was studied.