Abstract: Important buildings in high seismic regions usually use reinforce concrete (RC) frame-shear wall structural system. Through the introduction of seismic isolation technology for the design of such buildings, it has become a critical issue to meet the requirements for normal use under the design basis earthquake (DBE), which is regulated in the Regulations of Administration of Seismic Management of Construction Projects, and even realize a high resilience performance under the maximum considered earthquake (MCE). A RC frame-shear wall project located in the 8 degree region was selected as the example of this research, and the corresponding seismic resilience performance was assessed under DBE and MCE. Based on these, three design concepts were recommended to design the superstructure of isolated RC frame-shear wall buildings, and three cases were designed following these concepts for this building. Subsequently, the seismic resilience performance of three cases was assessed under DBE and MCE. The results indicate that the traditional seismic structure cannot meet the normal use requirements under DBE and the associated resilience level is Level 1. For the isolated buildings, when the sectional dimensions of superstructure and corresponding reinforcements are designed according to the one-degree lowering limit, 3.1 days are required for the restoration of normal use function under DBE, and the resilience level of such isolated structure under MCE is Level 2. When the sectional dimensions of superstructure are designed according to the half-degree lowering limit, and corresponding reinforcements are designed according to the one-degree lowering limit, the building can basically function well without interruption and meet the normal use requirements, but the resilience level of such structure under MCE remains Level 2. When the sectional dimensions of superstructure are designed according to the none lowering limit, and corresponding reinforcements are designed according to the one-degree lowering limit, the building can be fully functional without any interruption and meet the normal use requirements. Furthermore, the resilience level of such structure under MCE can be successfully improved to Level 3. The results of this study can provide reference for further investigation on the resilience-based seismic design of RC frame-shear wall structures in high seismic regions.