Abstract: Precast concrete frame structures are widely used in China. At present, it is mainly designed and calculated according to the principle of equivalent cast-in-place. However, the difference in structural response caused by different nodal nonlinear behavior cannot be ignored. Considers the difference between the nonlinear behavior of two types of typical fabricated joints and cast-in-place joints and studies the influence of these differences on the seismic response of frame structures. For emulated connection joints, the force mechanism of the joints is analyzed based on their structural forms, and the differences between the cast-in-situ joint and the emulated joint in the test phenomenon is explained accordingly. Two types of non-dimensional hysteretic models of the joints are proposed. Existing test results verify the rationality of the proposed model. For non-emulated joints, the mechanical behavior of an unbonded post-tensioned prestressed hybrid precast concrete beam-column connection is systematically studied. The nonlinear dynamic time history analysis method is adopted to reveal the differences between precast frames and cast-in-place frames in terms of structural displacement responses, of beam-column ductility requirements, and of residual deformations. The research results have practical reference value for the application of precast frame structures in areas of high seismic intensity.