Abstract: In order to study the influence of surrounding buildings on the shape factor of wind loading of a large-span coal shed, the shape factor of wind loading under four typical incoming wind directions have been carried out through the computational fluid dynamics (CFD) method, which is based on a large-span coal shed project in a power plant as the background. The influence of interference and of no interference, of more interference, and of less interference conditions on the shape factor of wind loading for a large-span coal shed is studied. The study results show that: the maximum positive shape factor of wind loading appears on the windward surface of the structure surface; the surrounding interference makes it decreased and blocked under the certain wind directions; the largest negative shape factor of wind loading appears on the top of the structure or the leading edge of the upper surface on the windward side; the surrounding interference has a weaker effect on the maximum negative shape factor of wind loading.