Abstract: To study the hysteretic behavior of high-strength steel framed-tube structures with replaceable double-channel shear links (HSS-FTS-RDSLs), the finite element model of a 2/3-scale one-story one-span HSS-FTS-RDSL sub-structure specimen was established by using the finite element analysis software ABAQUS, and the accuracy and applicability were verified. The cyclic constitutive model of the steel used in the link web was obtained through cyclic loading tests. 16 full-scale finite element models were developed to analyze the effects of the link length ratio, the span-to-height ratio of the spandrel beam, the spacing of link web stiffeners, the bolt diameter and the thickness of reinforcement-plate at the web-bolted connections on hysteretic behavior. The results demonstrate that the HSS-FTS-RDSL sub-structure dissipates earthquake energy by inelastic deformation of the link while the remaining components remain essentially elastic. With the increase of link length ratio, the bearing capacity, stiffness and energy dissipation capacity of the structure gradually decrease, and the overstrength factor of the link also decrease. It is suggested that the length ratio of the link be between 0.84 and 1.40. The double-channel link can be well employed in the spandrel beam with a span-depth ratio less than 4.6. The stiffener spacing has limited effect on the bearing capacity, stiffness and energy dissipation capacity of the structure. Reducing the bolt diameter results in the early bolt slippage at the connections, but has little influence on bearing capacity and stiffness. Reducing the thickness of the reinforcing-plate at connections increases the connection deformation and decreases the plastic deformation of the link.