Abstract: The paper analyzes the rolling bearing contact mechanical model under the misaligned loads in the strip rolling process, and establishes the Hertz ideal contact model of four-row cylindrical roller bearings for back-up roller and the bearing mechanical model under the misaligned loads using flexibility matrix method. The numerical simulations under different loads between the rolls are conducted, and the ideal contact process and the misaligned load contact process are simulated. The results show that the misaligned loads affect the bearing loads distribution of each row; the rolling body at 15°-30° position angles bears the maximum force where the maximum contact stress exhibits an "M" shape distribution. The simulation results are consistent with the numerical simulation results, but the later is bigger than the former by 15% or less, which is within the error scope of engineering application. As the rolling load increases, the total radial force on the rollers of the same row of bearings increases, and the misaligning of loads become more significant. The research provides theoretical basis for prolonging the life of bearings and ensuring the stable operation of rolling mills.