Abstract: To realize the seismic damage analysis of steel reinforced concrete (SRC) frames with special-shaped columns, a damage model which can reflect the migration and evolution of the member damage, the floor damage and the whole frame damage was established by using the weighted coefficient method. Seismic damage tests and finite element simulation were carried out on two SRC frames with special-shaped columns. The moment-rotation hysteresis curves of the beams and the horizontal load-displacement hysteresis curves of the columns were obtained. The seismic damage index of specimens was calculated and analyzed. The results show that the change law of the damage index of members, floors and the whole frame were in good agreement with the failure development processes of the specimens, indicating that the seismic damage model of the SRC frame with special-shaped columns is reasonable. Based on the failure states of the specimens and the seismic damage analysis results, the range of the damage index of SRC frames with special-shaped columns corresponding to five performance levels was proposed. It provides the basis for the post-earthquake damage assessment of this type of structure.