Abstract: As the excavation damaged zone (EDZ) of the surrounding rock is required to be as low as possible for the geological disposal of high-level radioactive waste, the blasting theory was studied deeply with the cutting seam cartridge technology. Taking the Beishan exploration tunnel (BET) as an example, the blasting parameters were designed by the cutting seam cartridge technology. A rock failure criterion was proposed especially for judging the rock crack initiation and propagation, where the dynamic mechanical parameters were adopted.Furthermore, a blasting test was carried out under the same tunnel face with the left and right sides, which correspond to the common cartridge and cutting seam cartridge, respectively. It is found that the blasting effect of the cutting seam cartridge is better than the other side, which verified the cutting seam cartridge technology. Moreover, with the surrounding rock EDZ and blasting vibration monitoring, the EDZ area and blasting vibration velocity of the cutting seam cartridge were much smaller than those of the other side. The results and the theoretical knowledge can be applied to the blasting and excavation of deep geo-engineering and the High-Level radioactive Waste geo-disposal.