Abstract: High Performance Fiber Reinforced Concrete (HPFRC) is an ideal material with high energy dissipation capacity for the characteristics of high tensile ductility and fine multiple cracking. A new aseismic structure,reinforced concrete (RC) frame-energy dissipation wall made with HPFRC, was proposed. Quasi-static tests were conducted on two one-half scale RC frame-HPFRC energy dissipation wall specimens. The aseismic behavior, such as the failure mechanism, deformation, energy dissipation, and the effective stiffness at the peak load, was analyzed. Test results indicate that RC frame-HPFRC energy dissipation wall structures can achieve the aseismic fortification objective of the middle damage under a rare earthquake. Compared with the RC frame with one energy dissipation wall, the RC frame infilled with two energy dissipation walls has a higher aseismic behavior. The lateral peak load increases by 38.3%; the initial stiffness increases 178%, and lateral stiffness after yield only increases 20%~30%; the energy dissipation capacity at different damage states increase 10%~175%; but, the lateral deformation capacity is basically identical. The effective stiffness coefficients of RC frame and HPFRC energy dissipation wall at peak load are 0.11 and 0.13, respectively.