Abstract: Earthquake disaster is one of the most important threats to the cities in China. Scientific and rational urban seismic damage simulation method can provide useful results for the earthquake prevention and mitigation. After a brief introduction to four regional seismic analysis methods, this study compared the analysis outcomes of four methods (e.g. damage probability matrix method, HAZUS method, multi-story concentrated-mass shear (MCS) model, multiple degree-of-freedom (MDOF) flexural-shear model) of typical structures and a specific region. The analysis results show that: 1) MDOF flexural-shear model is the most precise method among the four methods of regional seismic damage simulation. In this method, the model parameters are determined based on the multi-story buildings of China. Moreover, flexural-shear deformation mode of tall buildings is considered in this method. Therefore, the MDOF flexural-shear model is the suggested method for regional seismic damage prediction of the city in China. 2) Compared to the damage probability matrix method, other three methods can take the characteristics of the buildings in the target region into account. 3) Because the parameter determination of the MCS model is based on the parameter database of HAZUS, the seismic damage simulation results of these two methods are roughly close. Nonetheless, compared to the HAZUS method, the MCS model can consider the effect of the number of stories on the backbone curves more precisely.