Abstract: Structural multi-scale calculation technology can reduce computational costs greatly, and has a guarantee of calculation accuracy at the same time. In this study, a systematic method that connects the interface of the multi-scale model of reinforced concrete columns and defines the detailed region by introducing the equivalent plastic hinge length is proposed, and a multi-axial damage model of concrete is developed through secondary development of LS-DYNA. Thus, a multi-scale modeling method is established for seismic failure analysis of reinforced concrete columns. To verify the applicability of the proposed method, quasi-static tests and monotonic pushover numerical tests of reinforced concrete columns are simulated and analyzed by contrasting the simulation results with the test results. Finally, earthquake simulation shaking table tests of reinforced concrete columns are simulated and analyzed, and the results show that the failure process of reinforced concrete columns such as concrete crushing and steel bar buckling can be directly observed under strong earthquake loading.