Abstract: In this work the ground motions recorded in the hardest-hit Regions of Wenchuan, Lushan and Ludian Earthquakes are collected. The seismic damage of Ludian Earthquake is briefly introduced. Six two-dimensional reinforced concrete (RC) frames and one three-dimensional RC frame are taken as examples to compare the destructive power of the ground motions. The analysis results show that the ground motion of Wenchuan Earthquake is the most destructive, followed closely by Ludian Earthquake, while that of Lushan Earthquake is the least destructive. Based on the above results, discussions and suggestions are presented on the important related issues, such as the emergency response of earthquake, evaluation of seismic intensity degrees, seismic intensity measures and structural seismic designs.