Abstract: Fire is one of the main threats to the safety of high-rise structures. The mechanical response of a building under fire is the behavior of the overall structure of which the main feature is that the structural stiffness and bearing capacity of heated sub-structures vary with the fire development and in turn lead to the redistribution of the internal forces within the structural system. Currently, the relevant researches about the fire resistance of structural members of high-rise structures have been performed, but the study of the overall fire resistance performance of high-rise concrete structures is rare. In this paper, the fiber beam model and the multi-layer shell model that allow for the effect of high temperature are used to analyze the overall fire resistance performance of a high-rise concrete structure. Through simulating the different parts of the overall structure under the standard fire scenario, a comparative analysis of the fire resistance of super tall structures is taken. Finally, Pushdown method is used to analyze the collapse-resistant capacity under fire.