Abstract: This paper presents a general project review of Hong Kong-Zhuhai-Macao Bridge and the specialized design of composite steel piles. Based on the result of site investigation, data collection, theoretical calculation and numerical simulation, indoor and outdoor physical model test, the mechanical properties experiment and theoretical analysis of large diameter composite steel piles has been performed. The interaction mechanism of steel pipe and concrete have been studied, and the calculating method has been proposed and verified for the compressive stiffness, bending stiffness and the vertical and horizontal bearing capacity of composite steel pile. This research will contribute to improving the design calculation theory, optimizing the construction technology, revising relevant specifications, broadening the application scopes of composite steel piles.